Aquaporin five deficiency suppresses fatty acid oxidation and delays liver regeneration through the transcription factor PPAR.

ABSTRACT: After 70% partial hepatectomy (PHx), the metabolic pathways leading to hepatocyte lipid droplet accumulation during liver regeneration remain unclear. Aquaporin 5 (Aqp5) is an aquaporin that facilitates the transport of both water and hydrogen peroxide (H₂O₂). In this study, we observed delayed liver regeneration following PHx in Aqp5 knockout (Aqp5^-/-) mice. Considering the role of Aqp5 in H₂O₂ transport, we hypothesized that deficiency in Aqp5 may induce oxidative stress and hepatocyte injury. Through the measurement of reactive oxygen species (ROS) and redox-related indices, we observed significant alterations in ROS levels as well as malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) concentrations in

SUBMITTER: Li B 

PROVIDER: S-EPMC11930093 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature