BUB1B promotes cisplatin resistance in gastric cancer via Rad51-mediated DNA damage repair.

ABSTRACT:

Background

Cisplatin resistance significantly impedes the treatment of gastric cancer (GC). This work examined the possible therapeutic target status and function of BUB1B in controlling cisplatin resistance.

Methods

Following the identification of differentially expressed genes (DEGs), protein-protein interaction (PPI) network analysis was conducted using datasets from the Cancer Genome Atlas-stomach adenocarcinoma (TCGA-STAD), GSE51575, and GSE79973. Functional tests assessed the effect of BUB1B overexpression and knockdown on the GC cells. Enrichment analysis and RNA-seq identified pathways linked to BUB1B. Additionally, the function of BUB1B in GC cells resistant to cisplatin in regulating DNA repair was examined, as its relationship with Rad51 inhibitor (B02) in regulat

SUBMITTER: Qin Z 

PROVIDER: S-EPMC11930193 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature