NCBP2 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis.

ABSTRACT:

Background

The cap-binding complex (CBC) plays a crucial role in facilitating gene expression by safeguarding mRNA from nonsense-mediated decay, promoting mRNA splicing, 3'-end processing, and facilitating nuclear export. Nevertheless, the precise biological functions and clinical implications of CBC in cancer remain ambiguous, necessitating further investigation for clarification.

Methods

The present study utilized the cBioPortal database to investigate the genetic alterations of nuclear cap binding protein subunit 2 (NCBP2) in pan-cancer. The Cancer Genome Atlas (TCGA) and online web tools were employed to analyze the correlation between NCBP2 and prognosis, genome instability, immune infiltration, immune response, cancer stemness, and chemotherapeutic efficacy in pan-canc

SUBMITTER: Li S 

PROVIDER: S-EPMC11930219 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature