Total Synthesis of Marformycins A and D.

ABSTRACT: We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A (1) and marformycin D (2) using a solid-phase approach. A scalable solution-phase synthesis of the γ-hydroxypiperazic acid subunit in 2, starting from cis-hydroxyproline, is also described. Structural analysis of 1 and its Leu-epi congener demonstrates conformational differences that may underlie their divergent antimicrobial activities. The described approach enables further development of conformation-activity relationships within this class of depsipeptide natural products.

SUBMITTER: Anwar AF 

PROVIDER: S-EPMC11930286 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature