Tracing specificity of immune landscape remodeling associated with distinct anticancer treatments.

ABSTRACT: Immune cells within the tumor microenvironment impact cancer progression, resistance, response to treatments. Despite remarkable outcomes for some cancer patients, immunotherapies remain unsatisfactory for others. Here, we designed an experimental setting using the Alb-R26 ^Met "inside-out" mouse model, faithfully recapitulating molecular features of liver cancer patients, to explore the effects of distinct anticancer targeted therapies on the tumor immune landscape. Using two treatments in clinical trials for different cancer types, Decitabine and MEK+BCL-XL blockage, we show their capability to trigger tumor regression in Alb-R26 ^Met mice and to superimpose distinct profiles of immune cell types and immune-checkpoints, impacting immunother

SUBMITTER: Cannet F 

PROVIDER: S-EPMC11930375 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature