The J-shaped relationship between the gamma-glutamyltransferase to high-density lipoprotein cholesterol ratio and mortality risk in U.S. adults.

ABSTRACT:

Background

Research has investigated the gamma-glutamyltransferase to high-density lipoprotein cholesterol (GGT/HDL-C) ratio concerning metabolic diseases. This study aims to explore its effects on mortality, including cardiovascular disease (CVD) mortality.

Methods

A retrospective cohort study was conducted utilizing data from the National Health and Nutrition Examination Survey (1999-2018), comprising 50,462 U.S. adults. Survival outcomes were assessed through Kaplan-Meier curves, and a multivariable Cox proportional hazards model was employed to analyze the relationship between GGT/HDL-C levels and mortality risk. Restricted cubic splines and hierarchical analyses were utilized to explore potential non-linear associations and interactions, respectively.

Results

Dur

SUBMITTER: Qiu S 

PROVIDER: S-EPMC11930428 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature