The effects of coagulation factors on the risk of Alzheimer's disease: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies indicate a complex relationship between coagulation factors and Alzheimer's disease (AD). However, the current findings are inconsistent, and it remains uncertain whether a causal relationship exists.

Objective

This study utilizes a Mendelian randomization analysis to investigate the causal relationships between blood levels of coagulation factors and AD risk.

Methods

Eleven coagulation factors with valid instrumental variables available were evaluated. Two independent cohorts of European ancestry with AD genome-wide association study (GWAS) summary statistics were used: UK Biobank (UKB, N = 472,868) and the International Genomics of Alzheimer's Project (IGAP, N = 63,926). We primarily conducted Mendelian randomization (MR) analyses us

SUBMITTER: Shi W 

PROVIDER: S-EPMC11930485 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature