Differential Functional Connectivity of Frontolimbic Circuit During Symptom Provocation in Distinct Symptom Profiles of Obsessive-Compulsive Disorder: Connectivite fonctionnelle differentielle du circuit frontolimbique durant la provocation de symptomes dans des profils symptomatiques distincts du trouble obsessionnel-compulsif.

ABSTRACT: BackgroundEmotional processing deficits and frontolimbic dysfunction have been observed in patients with obsessive-compulsive disorder (OCD), with inconsistent evidence possibly due to symptom heterogeneity. We compared the functional activation and connectivity patterns of the frontolimbic structures during symptom provocation between patients with distinct symptom profiles of OCD.MethodsThirty-seven symptomatic OCD subjects were recruited and categorized based on predominant symptom profiles to contamination/washing symptom group (OCD-C, n = 19) and taboo thoughts group (OCD-T, n = 18), along with 17 healthy controls (HCs). All subjects were evaluated with comprehensive clinical assessments and functional magnetic resonance imaging while appraising personalized disorder-specific stimuli

SUBMITTER: Spurthi Thatikonda N 

PROVIDER: S-EPMC11930489 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature