Unveiling the Hidden Mechanism: How LuxS/AI-2 quorum sensing system drives antimicrobial resistance in Salmonella pullorum through activation of the efflux pump AcrAB-TolC.

ABSTRACT: Understanding the antimicrobial resistance (AMR) mechanism of Salmonella pullorum (SP), which is widespread among yellow chickens in China, is crucial for reducing significant economic losses in the industry. In this study, we explored the AMR mechanism by which the LuxS/AI-2-mediated quorum sensing (QS) system regulates the AcrAB-TolC efflux pump in the SP. The results showed that the luxS gene and the signaling molecule AI-2 had no effect on the growth of the SP strains. However, the luxS gene knockout strain (SP129∆luxS) was sensitive to antimicrobials (ampicillin, methoxypyrimidine, sulfaisoxazole, trimethoprim/sulfamethoxazole and nalidixic acid), whereas SP129 was resistant. The SP129 strain was resistant to antimicrobials which had previously been proved to be sensitive to the antim

SUBMITTER: Xu Z 

PROVIDER: S-EPMC11930582 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature