Opioid-associated cardiac arrest: A systematic review of intra-arrest naloxone and other opioid-specific advanced life-support therapies.

ABSTRACT:

Aim

Cardiac arrest due to opioid toxicity is a leading cause of life-years lost in many countries. Since the pathophysiology of cardiac arrest from opioid toxicity is different than primary cardiac etiologies, we sought to identify opioid-specific resuscitative interventions demonstrating benefit.

Methods

We searched Medline, EMBASE, CENTRAL, and the Web of Science (September 2024) for randomized or observational studies examining the benefit of opioid-specific advanced life support-level therapies for cardiac arrest. The primary and secondary outcomes were favourable neurological outcomes and survival at 30-days or hospital discharge, respectively. Risk of Bias and Certainty of Evidence were assessed with the ROBINS-I tool and GRADE methodology, respectively.

Results

SUBMITTER: Grunau B 

PROVIDER: S-EPMC11930592 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature