Early and rapid initiation of quadruple therapy for heart failure with reduced ejection fraction: A real-world experience.

ABSTRACT:

Objectives

To evaluate the feasibility, safety and efficacy of early and rapid initiation of quadruple therapy (four drugs in 4 weeks - '4×4 approach') for heart failure with reduced ejection fraction (HFrEF) patients in a real-world clinical setting.

Design

Prospective service evaluation study.

Setting

Secondary care.

Participants

Consecutive patients with de novo HFrEF between March and August 2021.

Intervention

'4×4 approach' - individualised initiation and up-titration of four pillars of HFrEF therapy by heart failure specialist.

Main outcome

Proportion of patients initiated on four pillars of HFrEF therapy within 4 weeks.

Results

Of 100 patients approached, 19 patients were not suitable for the rapid initiation and up-titration pathway

SUBMITTER: Sze S 

PROVIDER: S-EPMC11930596 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature