Genetic characterization on the nucleoprotein and fusion gene of wild-type measles virus circulating in Shanghai, 2001-2022.

ABSTRACT: Measles is an acute and highly contagious viral disease that poses significant public health challenges globally. Since 2001, continuous virologic surveillance has been conducted in Shanghai, enabling a comprehensive analysis of the evolution of the nucleoprotein (N gene) and fusion gene (F gene) of the measles virus (MeV) over a 21-year period. Between 2001 and 2022, there were a total of 1405 MeV strains isolated by the Shanghai Center for Disease Control and prevention (SCDC), including 6 strains of genotype D8, 8 strains of genotype B3, 12 strains of genotype H1b, and the remaining strains of genotype H1a. Reverse transcription polymerase chain reaction (RT-PCR) was used to amplify the 3' end of the N gene (450 nt) and the complete sequence of the F gene (1622 nt) from the viral isolat

SUBMITTER: Li Y 

PROVIDER: S-EPMC11930667 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature