Distinct gut microbiome features characterize <i>Fasciola hepatica</i> infection and predict triclabendazole treatment outcomes in Peruvian patients.

ABSTRACT:

Background

Fasciola hepatica, a globally distributed helminth, causes fasciolosis, a disease with significant health and economic impacts. Variability in triclabendazole (TCBZ) efficacy and emerging resistance are remaining challenges. Evidence suggests that the gut microbiome influences host-helminth interactions and is associated with anthelmintic effects, but its association with human F. hepatica infection and TCBZ efficacy is not well understood.

Methods

In this study, we investigated the relationship between Fasciola hepatica infection and the gut microbiome through metagenomic shotgun sequencing of 30 infected and 60 age- and sex-matched uninfected individuals from Peru. Additionally, we performed a longitudinal analysis to evaluate microbiome dyn

SUBMITTER: Lee G 

PROVIDER: S-EPMC11931013 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature