Plasma lipidomic alterations during pathogenic SIV infection with and without antiretroviral therapy.

ABSTRACT:

Introduction

Lipid profiles change in human immunodeficiency virus (HIV) infection and correlate with inflammation. Lipidomic alterations are impacted by multiple non-HIV-related behavioral risk factors; thus, use of animal models in which these behavioral factors are controlled may inform on the specific lipid changes induced by simian immunodeficiency virus (SIV) infection and/or antiretroviral therapy (ART).

Methods

Using ultrahigh Performance Liquid Chromatography-Tandem Mass Spectroscopy, we assessed and compared (ANOVA) longitudinal lipid changes in naïve and ART-treated SIV-infected pigtailed macaques (PTMs). Key parameters of infection (IL-6, TNFa, D-dimer, CRP and CD4⁺ T cell counts) were correlated (Spearman) with lipid concentrations at critical time po

SUBMITTER: Sivanandham S 

PROVIDER: S-EPMC11931036 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature