Identification and validation of prognostic biomarkers related to tumor immune invasion in pancreatic cancer.

ABSTRACT:

Background

The diagnosis and treatment of pancreatic adenocarcinoma (PAAD) remain clinically challenging, and new molecular markers for prognostic assessment and targeted therapy are urgently needed. The tumor microenvironment (TME) and immune invasion play an important role in pancreatic cancer development and progression. Therefore, immunotherapeutic strategies based on the TME and immune invasion may have important clinical value.

Methods

In this study, we extracted transcriptome and clinicopathological data for 179 PAAD samples from the TCGA database and evaluated the immune composition, stromal composition, and infiltrating immune cell landscape in the tumor samples. Then, we identified relevant differentially expressed genes (DEGs) and performed functional annotation a

SUBMITTER: Chen M 

PROVIDER: S-EPMC11931078 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature