Association of blood carboxyhemoglobin levels with mortality and neurological outcomes in out-of-hospital cardiac arrest.

ABSTRACT:

Background

Carbon monoxide (CO), produced endogenously by heme oxygenase-1, plays a crucial role in the immune system by mitigating cellular damage under stress. However, the significance of carboxyhemoglobin (COHb) levels after out-of-hospital cardiac arrest (OHCA) is not well understood. This study aimed to explore the association between COHb levels at hospital arrival and within the first 24 h post-arrival with 30-day mortality and neurological outcomes in patients who experienced OHCA.

Methods

This single-center, retrospective study analyzed data from adult patients who experienced OHCA seen at Okayama University Hospital from 2019 to 2023. The patients were assigned to one of two study groups based on COHb levels (0.0% or ≥0.1%) upon hospital arrival. The primary outco

SUBMITTER: Hongo T 

PROVIDER: S-EPMC11931083 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature