Inhibition of carbohydrate digestive enzymes by a complementary essential oil blend: in silico and mixture design approaches.

ABSTRACT:

Background

The increasing demand for natural alternatives in diabetes treatment has driven research into plant-derived metabolites, particularly essential oils (EOs) with bioactive properties. This study aims to optimize an EO mixture for inhibiting two key enzymes involved in glucose digestion: pancreatic α-amylase and intestinal α-glucosidase.

Methods

Essential oils were extracted from three Moroccan medicinal plants: false yellowhead (Inula viscosa L.), rose geranium (Pelargonium graveolens L'Hér.), and lemongrass (Cymbopogon citratus (DC.) Stapf.). Gas chromatography-mass spectrometry (GC-MS) analysis identified key metabolites in each EO. A statistical mixture design was employed to evaluate different EO ratios for their inhibitory effects on α-amyl

SUBMITTER: Loukili EH 

PROVIDER: S-EPMC11931151 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature