A Retrospective Evaluation of Serum Symmetric Dimethylarginine Concentration in Dogs With Protein-Losing Enteropathy.

ABSTRACT:

Background

Serum symmetric dimethylarginine (SDMA) is abnormally increased in people with inflammatory bowel disease (IBD). Changes in dogs with gastrointestinal disease, such as protein-losing enteropathy (PLE), have not been assessed.

Objectives

Evaluate SDMA concentration in non-azotemic dogs with PLE.

Animals

A total of 127 client-owned dogs, 17 with PLE, 34 controls matched for age, breed, sex, and neuter status, and 76 additional controls for multiple linear regression modeling.

Methods

Retrospective case-control study. The clinical records of a United Kingdom referral hospital were reviewed. Dogs with azotemia or prior glucocorticoid or immunosuppressive treatment were excluded. Dogs diagnosed with PLE that had serum symmetric dimethylarginine (SDMA) con

SUBMITTER: Park YJ 

PROVIDER: S-EPMC11931192 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature