Voluntary locomotion induces an early and remote hemodynamic decrease in the large cerebral veins.

ABSTRACT:

Significance

Behavior regulates dural and cerebral vessels, with spontaneous locomotion inducing dural vessel constriction and increasing stimulus-evoked cerebral hemodynamic responses. It is vital to investigate the function of different vascular network components, surrounding and within the brain, to better understand the role of the neurovascular unit in health and neurodegeneration.

Aim

We characterized locomotion-induced hemodynamic responses across vascular compartments of the whisker barrel cortex: artery, vein, parenchyma, draining, and meningeal vein.

Approach

Using 2D-OIS, hemodynamic responses during locomotion were recorded in 9- to 12-month-old awake mice: wild-type, Alzheimer's disease (AD), atherosclerosis, or mixed (atherosclerosis/AD) models. Within

SUBMITTER: Eyre B 

PROVIDER: S-EPMC11931294 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature