Evaluation of an antibody to α₄β₇ in the control of SIVmac239-<i>nef-stop</i> infection.

ABSTRACT: Treatment of SIV-infected rhesus macaques with short-term antiretroviral therapy (ART) and partially overlapping infusions of antibody to integrin α₄β₇ was reported to induce durable posttreatment viral suppression. In an attempt to replicate those observations, we treated macaques infected with the same virus and with the same ART and monoclonal antibody (mAb) regimens (anti-α₄β₇ versus control mAb). Sequencing demonstrated that the virus used was actually SIVmac239-nef-stop, not wild-type SIVmac239. A positive correlation was found at 2 weeks after infection between the frequency of repair of attenuated Nef-STOP virus to pathogenic Nef-OPEN and plasma SIV RNA levels. Levels of plasma viremia before the first antibody infusi

SUBMITTER: Di Mascio M 

PROVIDER: S-EPMC11931412 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature