Real-world effectiveness of CDK4/6i in first-line treatment of HR+/HER2- advanced/metastatic breast cancer: updated systematic review.

ABSTRACT:

Aim

Since 2021, additional real-world evidence (RWE) has emerged on the effectiveness of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) as first-line treatment of HR-positive/HER2-negative (HR+/HER2-) advanced/metastatic breast cancer (A/MBC), necessitating this updated review.

Methods

MEDLINE^®, Embase^®, and Cochrane Databases (07/06/2019-01/09/2024), and key congresses (2020-2024) were searched. Studies reporting first-line CDK4/6i use, over 100 participants, and progression-free survival (PFS) and/or overall survival (OS) data were included.

Results

This update included 82 unique studies, 42.7% for palbociclib, 7.3% for ribociclib, and 3.7% for abemaciclib; 46.3% assessed multiple CDK4/6i. In studies including multiple CDK4/6is, median PFS wa

SUBMITTER: Harbeck N 

PROVIDER: S-EPMC11931418 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature