Microultrasonography-Guided vs MRI-Guided Biopsy for Prostate Cancer Diagnosis: The OPTIMUM Randomized Clinical Trial.

ABSTRACT:

Importance

High-resolution microultrasonography-guided biopsy is an alternative to MRI fusion-guided biopsy for prostate cancer diagnosis.

Objective

To compare microultrasonography-guided and MRI fusion-guided biopsy.

Design, setting, and participants

A multicenter, international, open-label, randomized, noninferiority trial of biopsy-naive men from 20 centers (8 countries) with clinical suspicion of prostate cancer (elevated prostate-specific antigen [PSA] and/or abnormal digital rectal examination findings) from December 2021 to September 2024.

Interventions

Participants were assigned to receive either microultrasonography-guided biopsy (n = 121), microultrasonography/MRI fusion-guided biopsy (microultrasonography/MRI; n = 226, in which microultrasonography b

SUBMITTER: Kinnaird A 

PROVIDER: S-EPMC11931425 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature