Input-Specific Localization of NMDA Receptor GluN2 Subunits in Thalamocortical Neurons.

ABSTRACT: Molecular and functional diversity among synapses is generated, in part, by differential expression of neurotransmitter receptors and their associated protein complexes. N-methyl-D-aspartate receptors (NMDARs) are tetrameric ionotropic glutamate receptors that most often comprise two GluN1 and two GluN2 subunits. NMDARs generate functionally diverse synapses across neuron populations through cell-type-specific expression patterns of GluN2 subunits (GluN2A-2D), which have vastly different functional properties and distinct downstream signaling. Diverse NMDAR function has also been observed at anatomically distinct inputs to a single neuron population. However, the mechanisms that generate input-specific NMDAR function remain unknown, as few studies have investigated subcellular GluN2 subuni

SUBMITTER: Topolski MA 

PROVIDER: S-EPMC11931474 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature