Cancer Photodynamic Therapy Enabled by Water-Soluble Chlorophyll Protein.

ABSTRACT: Photodynamic therapy (PDT) has been utilized to treat various malignant cancers for more than a century. However, many photosensitizers (e.g., derivatives of porphyrins, chlorins, etc.) central to PDT are still suffering from limitations such as water insolubility, dark toxicity, photo/thermal-instability, difficult synthesis/preparation, and poor tumor selectivity. Numerous effective strategies include designing new synthetic photosensitizers by exploiting heavy atom effect, aggregation-induced emission effect (AIE), and electronic/energy effects (donor-acceptor, and Förster resonance energy transfer: FRET), and the linkage of activatable and targeting molecules has been developed to address one or more of these limitations. However, these structural modifications of photosensitizing orga

SUBMITTER: Liang L 

PROVIDER: S-EPMC11931482 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature