Prediction of survival with lower intensity therapy among older patients with acute myeloid leukemia.

ABSTRACT:

Background

The aim of this study was to develop a prognostic model for survival in older/unfit patients with newly diagnosed acute myeloid leukemia (AML) who were treated with lower-intensity chemotherapy regimens.

Methods

The authors reviewed all older/unfit patients with newly diagnosed AML who received lower-intensity chemotherapy from 2000 until 2020 at their institution. A total of 1462 patients were included. They were divided (3:1 basis) into a training (n = 1088) and a validation group (n = 374).

Results

In the training cohort of 1088 patients (median age, 72 years), the multivariate analysis identified 11 consistent independent adverse factors associated with survival: older age, therapy-related myeloid neoplasm, existence of previous myelodysplastic syndrome

SUBMITTER: Sasaki K 

PROVIDER: S-EPMC11931673 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature