Causal associations between gut microbiota and type 2 diabetes mellitus subtypes: a mendelian randomization analysis.

ABSTRACT:

Purpose

To investigate the causal relationships between gut microbiota and novel adult-onset type 2 diabetes mellitus(T2DM) subtypes.

Methods

We conducted Mendelian randomization (MR) analyses using genome-wide association data from European populations. Initial MR analyses examined associations between gut microbiota and four T2DM subtypes, followed by validation analyses using type 1 diabetes mellitus(T1DM) and T2DM GWAS data. We also performed bidirectional MR analyses and tested for heterogeneity and pleiotropy across all analyses.

Results

Our MR analyses revealed distinctive associations between gut microbiota and T2DM subtypes: six bacterial taxa with severe insulin-deficient diabetes (SIDD), four with severe insulin-resistant diabetes (SIRD), eight with mild ob

SUBMITTER: Ruan Z 

PROVIDER: S-EPMC11931760 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature