Metagenomic signatures of extraintestinal bacterial infection in the febrile term infant gut microbiome.

ABSTRACT:

Background

Extraintestinal bacterial infections (EBIs), e.g., urinary tract infection, bacteremia, and meningitis, occur in approximately 10% of febrile infants younger than 60 days. Although many EBI-causing species commonly reside in the infant gut, proof that the digestive system is a pre-infection habitat remains unestablished.

Results

We studied a cohort of febrile term infants < 60 days old who presented to one of thirteen US emergency departments in the Pediatric Emergency Care Applied Research Network from 2016 to 2019. Forty EBI cases and 74 febrile controls matched for age, sex, and race without documented EBIs were selected for analysis. Shotgun sequencing was performed of the gut microbiome and of strains cultured from the gut and extraintestinal site(s) of EBI c

SUBMITTER: DeVeaux AL 

PROVIDER: S-EPMC11931804 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature