Psychiatric morbidity in people with autoimmune arthritides as a model of inflammatory mechanisms in mental disorders.

ABSTRACT:

Background

Rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) are autoimmune illnesses characterised by chronic inflammation demonstrating differential associations with psychiatric conditions.

Objective

In this matched-cohort study, we aimed to investigate whether the associations between these inflammatory illnesses and mental disorders are predominantly the consequence of the burden of the former or whether common causes might underpin the susceptibility to both.

Methods

Using Czech national inpatient care data, we identified individuals with RA or axSpA during the years 1999-2012. We investigated the occurrence of psychiatric outcomes up to 2017 using stratified Cox proportional hazards models. In evidence triangulation, we assessed the potential modera

SUBMITTER: Formanek T 

PROVIDER: S-EPMC11931917 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature