Safety and effectiveness of multimodal opioid-free anaesthesia for pain and recovery after laparoscopic surgery: a systematic review and meta-analysis.

ABSTRACT:

Objectives

This study aimed to investigate the safety and effectiveness of opioid-free anaesthesia (OFA) versus conventional opioid anaesthesia (OA) for postoperative pain management and recovery in patients undergoing laparoscopic surgery.

Design

Systematic review and meta-analysis.

Data sources

The databases of PubMed, Embase, Cochrane Library and Web of Science were searched from inception to August 2023.

Eligibility criteria for selecting studies

We included any randomised controlled trial comparing OFA (at least two drugs or two more alternatives to opioids) with OA for laparoscopic surgery. The primary outcomes included postoperative pain scores, measured on a Numerical Rating Scale or Visual Analogue Scale ranging from 0 to 10, at 0-2 hours and 24 hours

SUBMITTER: Cheng L 

PROVIDER: S-EPMC11931934 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature