Clonal Evolution of Myeloid Malignancies Treated With Microtransplantation: A Single-Centre Experience.

ABSTRACT: Microtransplantation is a cellular therapy used in acute myeloid leukaemia and myelodysplastic syndromes as a maintenance therapy in patients ineligible for a regular allogeneic stem cell transplantation. We performed a monocentric retrospective study of acute myeloid leukaemia, myelodysplastic syndromes, and chronic myelomonocytic leukaemia patients who underwent microtransplantations at Nice University Hospital. We analysed the evolution of the disease mutational status after microtransplantation. We report 18 patients who underwent microtransplantation courses, with a total of 47 microtransplantations performed between February 2020 and June 2022. We observed long-term remissions even in high-risk patients. Founder mutations persisted throughout the follow-up, whereas it was more variab

SUBMITTER: Sammut R 

PROVIDER: S-EPMC11932058 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature