Comparative genomic analysis of emerging non-typeable <i>Haemophilus influenzae</i> (NTHi) causing emerging septic arthritis in Atlanta.

ABSTRACT:

Background

Haemophilus influenzae is a Gram-negative bacterium that can exist as a commensal organism or cause a range of diseases, from ear infections to invasive conditions like meningitis. While encapsulated H. influenzae strains have historically been linked to severe diseases, non-typeable Haemophilus influenzae (NTHi) strains, lacking an intact capsule locus, have emerged as the leading cause of invasive H. influenzae infections, particularly following the widespread use of the H. influenzae serotype b (Hib) vaccine.

Methods

In response to a significant increase in invasive NTHi infections among persons living with HIV in metropolitan Atlanta during 2017-2018, we conducted a comparative genomic analysis of two predominant NTHi clones,

SUBMITTER: Bixler BJ 

PROVIDER: S-EPMC11932112 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature