Energy Utilization in Premature Neonates Undergoing Screening for Retinopathy of Prematurity.

ABSTRACT:

Background/objectives

Premature neonates are at risk for retinopathy of prematurity (ROP) and routinely undergo screening exams that involve substantial physical manipulation, often causing significant signs of pain, despite pain-relieving interventions. It remains unclear whether these exams affect energy utilization, cellular hypoxia, and clinically significant events, and whether receiving supplemental oxygen affects these relationships. This work examines the effects of ROP screening on (1) urinary uric acid-to-creatinine concentration ratios ([UA]/[Cr]), a known marker of ATP degradation, hypoxia, and oxidative stress; and (2) clinically significant events (apnea, bradycardia, gastric residuals, and oxygen desaturations) in premature neonates on room air or oxygen support.

SUBMITTER: Pentecost AM 

PROVIDER: S-EPMC11932259 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature