Assessing the Application of Physiologically Based Pharmacokinetic Models in Acute Chemical Incidents.

ABSTRACT: Chemical release incidents in the United States involve hazardous chemicals that can harm nearby communities. A historical tracking of these chemical release incidents from 1991 to 2014 across up to 16 states has been conducted by The Agency for Toxic Substances and Disease Registry (ATSDR), utilizing the Hazardous Substances Emergency Events Surveillance (HSEES) and the National Toxic Substance Incidents Program (NTSIP) systems. By analyzing surveillance data, patterns of these different chemical releases can be identified to develop and construct a health-protective course of action. Physiologically Based Pharmacokinetic (PBPK) models can simulate chemical exposures during acute chemical incidents. For a retrospective study of an acute chemical release in 2012, we examined the components

SUBMITTER: Boone S 

PROVIDER: S-EPMC11932312 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature