A robust planning approach for respiratory motion in accelerated partial breast irradiation using volumetric modulated arc therapy.

ABSTRACT: Accelerated partial breast irradiation (APBI) is an alternative treatment for early-stage breast cancer. This study aimed to evaluate the effectiveness of the virtual bolus (VB) method and robust planning against respiratory motion in volumetric modulated arc therapy (VMAT)-APBI. VMAT plans were generated with 30 Gy in 5 fractions for 16 patients. Four treatment plans were developed and compared: a standard optimization (SO) plan without robust methods, a pseudo-skin flash strategy using a 5 mm VB (with densities of 0.4 and 1.0 g/cm3, VB04 and VB10), and a robust optimization (RO) plan to minimize penalties in worst-case scenarios. The isocenter was shifted 1-5 mm in each translational direction in robust analysis, and perturbed dose calculations were performed. All dose constraints for th

SUBMITTER: Yamauchi R 

PROVIDER: S-EPMC11932346 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature