Regenerative Peripheral Nerve Interface Surgery to Treat Chronic Postamputation Pain: A Prospective Study in Major Lower Limb Amputation Patients.

ABSTRACT:

Objective

The objective was to assess the postsurgical outcomes of regenerative peripheral nerve interface (RPNI) surgery in a prospective cohort of major lower extremity amputation patients with chronic postamputation pain.

Background

Chronic pain in lower limb amputation patients is commonly the result of neuroma formation after traumatic peripheral nerve injury. By implanting more proximal transected nerve ends into autologous free muscle grafts, RPNI surgery can treat postamputation pain by diminishing the development of neuromas. RPNI surgery in prior retrospective studies has been shown to mitigate postamputation pain.

Methods

Twenty-two lower limb amputation patients with established chronic postamputation pain were recruited from 2 studies in this prospective

SUBMITTER: Lee JC 

PROVIDER: S-EPMC11932616 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature