Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery.

ABSTRACT:

Background

Postoperative delirium is a recurring complication among vulnerable patients undergoing major cardiac surgery. While delirium has been associated with prodromal dementia, there is minimal evidence to support the causality of this nuanced relationship. Clarification as to how postoperative delirium might lead to neurodegenerative dementias, perhaps through evidence of contemporaneous biomarkers, would heighten the plausibility of a causal correlation. TAR DNA-binding protein 43 (TDP-43), a nuclear protein essential for transcriptional events, has been linked to pathological aggregation in Alzheimer's disease (AD) and AD-related dementias (ADRD).

Methods

Circulating TDP-43 levels in cardiac surgical patients aged 60 years and older were evaluated in a biobank derive

SUBMITTER: Simon C 

PROVIDER: S-EPMC11932660 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature