Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study.

ABSTRACT:

Background

Patients with type 1 diabetes mellitus have been at heightened risk for developing atrial fibrillation. We aimed to investigate whether this association is causal using Mendelian randomization.

Methods

Using publicly available genome-wide association studies data, we selected single nucleotide polymorphisms significantly associated with type 1 diabetes mellitus as instrumental variables. We employed inverse variance-weighted, weighted median, MR-Egger regression, simple mode, and weighted mode methods within a two-sample Mendelian randomization framework to assess the causal relationship between type 1 diabetes mellitus and atrial fibrillation. We evaluated the pleiotropy and heterogeneity levels of the included genetic instruments using MR-PRESSO, MR-Egger interc

SUBMITTER: Li Y 

PROVIDER: S-EPMC11932688 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature