Comparison of the capillary and venous blood plasma lipidomes: validation of self-collected blood for plasma lipidomics.

ABSTRACT: Venipuncture of the upper extremities is commonly used to collect blood for plasma lipidomics. However, self-administered blood collection devices such as the Tasso+™ system for capillary blood sampling and plasma separation are convenient and enable frequent sampling without a clinical blood draw. The purpose of this study is to validate Tasso+ sampling for plasma lipidomics by comparing the venous blood and Tasso+-sampled capillary blood plasma lipidomes. Lipids are proven or putative biomarkers of human health and disease and indicators of nutritional and toxicological status. Because exchange of blood components including lipids occurs in capillaries, the capillary and venous blood lipidomes might be different, which could confound use of Tasso+-sampled blood as a surrogate for venous

SUBMITTER: Hameed A 

PROVIDER: S-EPMC11932689 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature