Therapeutic effects of exosomes from angiotensin-converting enzyme 2 - overexpressed endothelial progenitor cells on intracerebral hemorrhagic stroke.

ABSTRACT:

Objective

We have previously demonstrated that angiotensin-converting enzyme 2 (ACE2) could boost the therapeutic effects of endothelial progenitor cells (ACE2-EPCs) on stroke. However, where this effect comes from is still unclear. Here, we investigated whether the exosomes (EXs) released from ACE2-EPCs could provide the benefit for acute intracerebral hemorrhagic stroke (ICH).

Methods

The C57BL/6 mice were induced ICH by collagenase injection, followed by intravenously administration of ACE2-EPC-EXs. ACE2 blocker, DX600 was used to verify the effects of ACE2. The neurological deficit score (NDS), hemorrhage volume, brain water content, and blood-brain barrier (BBB) permeability were measured at day 2 after injection. The levels of ACE2 and inflammatory factors/genes in the

SUBMITTER: Wang J 

PROVIDER: S-EPMC11932701 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature