Step-Down Therapy Using Vonoprazan for Giant Gastric Polyps in Long-Term Proton Pump Inhibitor Administration.

ABSTRACT:

Introduction

Gastroesophageal reflux disease (GERD) is diagnosed based on bothersome symptoms, such as heartburn, and the presence of mucosal breaks endoscopically. Treatments that suppress gastric acid, such as proton pump inhibitor (PPI) and vonoprazan, are frequently administered. Several studies reported regarding the safety and side effects of long-term PPI administration, including an association with gastric polyps. We report a case of maintained symptom resolution and significantly shrank gastric polyps by performing step-down therapy, which is minimal acid-suppressing treatment.

Case presentation

A female patient in her 60s had been taking PPI for reflux esophagitis for >10 years. An upper gastrointestinal endoscopy revealed two gastric polyps measuring 20 mm and 10

SUBMITTER: Kikuchi D 

PROVIDER: S-EPMC11932720 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature