UnifiedGreatMod: a new holistic modelling paradigm for studying biological systems on a complete and harmonious scale.

ABSTRACT:

Motivation

Computational models are crucial for addressing critical questions about systems evolution and deciphering system connections. The pivotal feature of making this concept recognizable from the biological and clinical community is the possibility of quickly inspecting the whole system, bearing in mind the different granularity levels of its components. This holistic view of system behaviour expands the evolution study by identifying the heterogeneous behaviours applicable, e.g. to the cancer evolution study.

Results

To address this aspect, we propose a new modelling paradigm, UnifiedGreatMod, which allows modellers to integrate fine-grained and coarse-grained biological information into a unique model. It enables functional studies by combining the analysis of the s

SUBMITTER: Aucello R 

PROVIDER: S-EPMC11932724 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature