Single-cell and transcriptome analyses revealed CTHRC1 a potential therapeutic target mediating invasion and tumor microenvironment in TNBC: experimental validation.

ABSTRACT:

Background

Investigating the pivotal role of CTHRC1 in the tumor microenvironment of triple-negative breast cancer (TNBC).

Method

The RNA transcriptomic data obtained from the Cancer Genome Atlas and single-cell sequencing data from TNBC in Gene Expression Omnibus (GEO) were acquired and subjected to analysis. A comprehensive investigation was conducted with a specific focus on characterizing CTHRC1 in TNBC and its correlation with invasive genes. Furthermore, additional analyses were performed to explore the relationship between CTHRC1, tumor immune cell infiltration, and immunotherapy in TNBC. The expression of CTHRC1 in the tumor microenvironment, cellular differentiation, and cellular communication was systematically analyzed using single-cell data from TNBC.

Result</

SUBMITTER: Wan H 

PROVIDER: S-EPMC11933001 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature