Response surface-based media optimization for astaxanthin production in <i>Corynebacterium glutamicum</i>.

ABSTRACT:

Introduction

Astaxanthin is a C40 carotenoid that is used in animal feeds or cosmetics. Due to its high antioxidant property it is used for, e.g., anti-aging formulations and due to its intense red color it is used, e.g., in animal feed. While about 95% of commercial astaxanthin is currently chemically synthesized from fossil sources, the interest in natural and sustainable astaxanthin is growing. Corynebacterium glutamicum, an attractive host used in large-scale processes, e.g., industrial amino acid production, has been engineered for astaxanthin production.

Methods

Here, a design of experiment (DoE) approach was applied to optimize the standard minimal medium for astaxanthin production. The concentrations of carbon, nitrogen and phosphorus sources, magnesium, calci

SUBMITTER: Meyer F 

PROVIDER: S-EPMC11933003 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature