Characterize neuronal responses to natural movies in the mouse superior colliculus.

ABSTRACT: While artificial stimuli have been widely used in visual neuroscience and have significantly advanced our understanding of visual processing, they differ dramatically from the natural scenes that animals encounter in the wild. How natural stimuli are encoded in the superior colliculus (SC) and how neuronal responses to artificial and natural stimuli are related remain poorly understood. Here I applied two-photon calcium imaging to record neuronal activity in the mouse superficial SC in response to natural movies. An unsupervised learning algorithm grouped recorded neurons into 16 clusters based on their response patterns. Each cluster exhibited distinct temporal profiles, which arose from differences in both receptive field coverage and how neurons encode local visual features. Interesting

SUBMITTER: Li YT 

PROVIDER: S-EPMC11933010 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature