Alteration of prefrontal functional connectivity in preclinical Alzheimer's disease: an fNIRS study.

ABSTRACT:

Background

Early detection of Alzheimer's disease (AD) is vital for delaying its progression through timely intervention. The preclinical stage, the longest phase of AD, often goes undetected due to a lack of noticeable symptoms. Developing an accessible and quantitative screening method for AD is essential for enabling appropriate interventions during this stage.

Methods

Functional near-infrared spectroscopy was used to investigate prefrontal functional connectivity in preclinical AD subjects. A total of 99 participants, including healthy controls and preclinical subjects who were amyloid beta (Aβ) positive (n = 45), were recruited. We designed a mixed phonemic and semantic verbal fluency task for the experimental protocol. Functional connectivity was then analyzed a

SUBMITTER: Kim M 

PROVIDER: S-EPMC11933025 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature