Jing-Yin-Gu-Biao formula protects mice from postinfluenza <i>Staphylococcus aureus</i> infection by ameliorating acute lung injury and improving hypercoagulable state via inhibiting NETosis.

ABSTRACT:

Background

Jing-Yin-Gu-Biao formula (JYGBF) is a Chinese medicine derived from Yupingfeng power, Huoxiangzhengqi powder and Yinqiao powder, and has been widely used to treat acute respiratory infections. This study aims to observe the effects of JYGBF against postinfluenza Staphylococcus aureus (S. aureus) infection.

Purpose and study design

A mouse model of secondary S. aureus infection following PR8 infection was established to evaluate the protective effects of JYGBF against postinfluenza Staphylococcus aureus (S. aureus) infection and related mechanisms were validated in vivo and in vitro.

Results

The administration of JYGBF significantly ameliorated acute lung injury (ALI) and inhibited overactivated inflammatory r

SUBMITTER: Lei B 

PROVIDER: S-EPMC11933027 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature