Discrepancies between human and murine model cerebral aneurysms at single-cell resolution.

ABSTRACT:

Background

The murine model of cerebral aneurysm (CA) serves as a prevalent tool for investigating the molecular underpinnings of CA. However, the extent to which the CA murine model aligns with that of human remains elusive.

Methods

The present study employed a comprehensive integration and exploration of the single-cell RNA-seq (scRNA-seq) datasets, along with multiple trajectory and gene regulatory network analyses, to investigate the cellular and molecular discrepancies between human and murine model CAs.

Results

The uniform manifold approximation and projection (umap) embedding exhibits that the primary discrepancies between human and murine model CAs reside in the cells of modifiable phenotype, encompassing vascular smooth muscle cell (vSMC), monocyte/macrophage

SUBMITTER: Ji H 

PROVIDER: S-EPMC11933115 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature