Burden of cancer attributable to infection in Japan in 2015.

ABSTRACT: Population attributable fraction (PAF) offers a means to quantify cancer burden that is attributable to a specific etiological factor. To better characterize the current cancer burden due to infection in the Japanese population, we estimated the PAF for cancer incidence and mortality in 2015 that could be attributable to infectious agents, including Helicobacter pylori (H. pylori), Hepatitis B and C (HBV/HCV), Human papillomavirus virus (HPV), Epstein- Barr virus, and human T-lymphotropic virus type 1. We estimated the PAFs for each infectious agent on the basis of representative data on prevalence and risk-outcome associations assuming a latency period of 10 years. Overall, 16.6% of cancer cases in 2015 in Japan were attributable to the infectious agents included in this analysis.

SUBMITTER: Lin Y 

PROVIDER: S-EPMC11933937 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature