Low-dose isotretinoin for the management of rosacea: A systematic review and meta-analysis.

ABSTRACT:

Background

Rosacea is a chronic, relapsing inflammatory dermatosis predominantly affecting the central face and can result in significant psychosocial impacts. Isotretinoin has been studied for rosacea due to its anti-inflammatory and sebum reduction properties, but its use remains limited likely due to its off-label use and potential adverse events.

Objective

This systematic review and meta-analysis investigated the efficacy and safety of low-dose isotretinoin (LDI; ≤0.5 mg/kg/day) for the four main types of rosacea: erythematotelangiectatic, papulopustular, phymatous and ocular rosacea.

Methods

Randomized and non-randomized studies evaluating LDI for rosacea were included. Incomplete studies, non-English studies and case reports were excluded. Study quality was asse

SUBMITTER: King A 

PROVIDER: S-EPMC11934015 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature