Cortistatin and plakinamine steroidal alkaloids from the marine sponges of the genus <i>Corticium</i>: insights into their chemistry, pharmacology, pharmacokinetics and structure activity relationships (SARs).

ABSTRACT: Cortistatins and plakinamines represent a unique class of marine-derived steroidal alkaloids, renowned for their structural diversity and potent pharmacological activities. This review provides a comprehensive overview of their chemical characteristics, pharmacological profiles, pharmacokinetics, and drug-likeness properties, with a particular focus on structure-activity relationships (SARs). Indeed, we explored their distinct molecular architectures and classification within the broader family of marine alkaloids, highlighting key subclasses and derivatives identified through advanced analytical techniques. Their broad-spectrum bioactivities, including anticancer, anti-inflammatory, antimicrobial, and antiviral effects, are discussed in detail, supported by insights into SARs and pharmaco

SUBMITTER: Tammam MA 

PROVIDER: S-EPMC11934034 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature